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Acknowledgements The authors gratefully acknowledge Mehdi Damaghi for the tumor spheroid model graphic (Figure 1A) and Mark Lloyd for the digital pathology graphic (Figure 1B)

However, the harmful effects of excessive trace elements are still not completely understood

Dermatomyositis is one of the five main clinicopathologically distinct inflammatory myopathies, the other four being (1) polymyositis, (based on the historical classification, even if now seemingly extinct), (2) necrotizing autoimmune myositis, (3) overlap myositis and the anti-synthetase syndromes, and (4) inclusion-body myositis (24)

Although they can both regulate cell apoptosis and cell cycle, cisplatin induces a large number of genes related to DNA damage, P53 and apoptosis, while some ruthenium complexes facilitate the expression of oxidative stress and ER stress ( The existing research achievements should be combined with molecular biology and nanomaterials, applying the advantage of existing tools and methods to develop antitumor drugs with better therapeutic effects, based on these complexes