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AlphaFold predictions of larger members of the 6-cysteine protein family will be useful to better understand the arrangement and three-dimensional organization of multiple 6-cysteine domains

The crotonylation of H3K9 was significantly enhanced by NaBu but suppressed by ACADS knockout, revealing that ACADS regulates histone 3-lysine 9-crotonylation (H3K9cr) [45]

Inestrosa, Pedro Cisternas International Journal of Molecular Sciences.2026

Functional MET channels are required for aminoglycoside ototoxicity, and increased channel open probability during acoustic stimulation enhances drug entry ( Once inside, aminoglycosides accumulate within hair cells to concentrations that persist for months owing to high-affinity binding to phosphatidylinositol 4,5-bisphosphate ( Mitochondrial dysfunction Aminoglycosides preferentially localize to mitochondria by binding to the 12S ribosomal RNA, which is encoded by the mitochondrially encoded gene MT-RNR1