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This could include weight loss of 1 to 2 pounds per week, improved waist circumference, and enhanced physical endurance

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In the first study, patients with night-eating syndrome ( n = 15) showed melatonin dysregulation and abnormalities in food intake and in leptin and insulin levels [72]

Prioritize rational combination strategies over single-agent approaches: Given metabolic plasticity, clinical development should focus on combinations targeting multiple metabolic pathways simultaneously or pairing metabolic inhibitors with complementary therapies