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doi: 10.1002/EXP.20210115 316 ZhengQ.WangX

*Correspondence: Liping Qu, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In this system, GEN (10 mol/L) could effectively reverse the resistance of the cells to fluorouracil and its mechanism of inhibits characteristics of liver cancer stem cells is likely involved in inhibiting protein expression of stem cell markers and obstructing Hedgehog signal pathway (Li et al., 2015)