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Formation of intracellular aggregates of various crystallin proteins was visualized by fluorescence of GFP (green) and the nuclei were stained with Hoechst 33342 (blue)

Archived from the original on March 11, 2016

This rate-limiting step is catalyzed by glutamate-cysteine ligase (GCL) a heterodimeric enzyme composed of a catalytic subunit encoded by GCLC and a modifier subunit encoded by GCLM