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Preclinical studies have indicated that these compounds markedly improve intervertebral disc structure and suppress inflammatory responses in animal models of IDD, highlighting their potential clinical applications (47,88)

This contrasts with the findings of our study regarding cotinine and BMD

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Most disease-causing mutations in these proteins occur in low-complexity domains mediating liquid-liquid phase separation to alter protein conformation, which promotes the aggregation and disrupts RNA regulation while also generating additional toxicity