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ALS-causative mutations in FUS/TLS are shown to abnormally enhance their interaction with SMN and dysregulate its function, including loss of Gems and altered levels of small nuclear RNAs

The stock solution was equilibrated at 37 C and 5% CO 2 for 24 h, aliquoted, and stored at 20 C for further use

2.5 ALT and AST enzyme activity measurement To evaluate the degree of hepatic injury, the serum enzyme activities of key hepatic enzymes, including alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were assessed

A shift in mitochondrial substrates and metabolic inflexibility causes DNA mutations, oxidative stress, and apoptosis in PTPMT1 knockout cells