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Treatment effects estimated using MMRM To supplement the treatment policy estimand, weight management clinical trials may report the placebo-adjusted weight loss that is expected when adhering to the treatment at the investigated dose under the assumption of no intercurrent events [3]

Several studies, such as this one, have reported significant pain with water-based injections, and little to no pain with those prepared in saline

Studies comparing localized versus systemic delivery for other biologics (botulinum toxin, platelet-rich plasma) suggest systemic routes produce more uniform results across larger treatment areas