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obinutuzumab frontline treatment ( EZH2 mutations were associated with more benefit from cyclophosphamide, adriamycin, vincristine and prednisone (CHOP)/cyclophosphamide, vincristine and prednisone (CVP) chemotherapy, whereas EZH2 wild-type patients had superior outcomes with bendamustine-based regimens ( More recently, genomically distinct subtypes of FL have been identified with different, often more favorable, treatment response ( STAT6 and CREBBP mutations, and usually has a good response to chemotherapy and RT ( IRF8 and frequent MAPK mutations with a surprising absence of epigenetic modifier mutations ( Marginal zone lymphomas In MZL, most ENMZLs show trisomy of chromosomes 3 and 18

shoulder function can usually be improved by a surgical repair