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GRP75 modulates endoplasmic reticulum-mitochondria coupling and accelerates Ca(2+)-dependent endothelial cell apoptosis in diabetic retinopathy

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To establish the link between this photo-oxidative stress and the cellular response, we introduced to the bacteria a plasmid that constitutively expresses the oxidative stress-related transcription factor OxyR, which can then turn on genes in the presence of H 2 O 2 as part of the oxidative stress response 38,39 (Fig

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