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22 However, epidemiological and clinical studies have linked hyperuricemia to the development of various conditions, including chronic kidney disease, fatty liver, metabolic syndrome, hypertension, insulin resistance, obesity, type 2 diabetes, and cardiovascular and cerebrovascular disorders

This was illustrated previously by the lack of inner ear phenotypes in mice deficient in either Wnt1 or Wnt3 , yet double knockouts exhibit overt abnormal development of the otocyst

This state is characterized by disrupted redox signaling, uncontrolled oxidation of biomolecules, and cellular damage

Selenocysteine-mediated native chemical ligation