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Description

Although excretion of NAcLys-BDA and NAcCys-BDA-Lys in our human pilot study increased in response to high furan intake, exposure estimates based on the abundance of these metabolites in human urine and relative excretion rates determined in F344/DuCrl rats by far exceeded current human exposures reported by EFSA (2017)

At least part of the protective effect is associated with flux through the carnitine acyltransferases, as analogs of L-carnitine that are competitive inhibitors of carnitine acyltransferases enhance the toxicity of acute ammonium admin