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The RCTs reviewed in the meta-analyses included in this work were routinely reported as having significant heterogeneity, low to moderate methodologies, and high risk of bias, including poor blinding of investigators and subjects, analytical methods, and poor control of confounding factors

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However, more research is still needed to fully prove it

Increasing evidence suggests that this axis exerts a profound influence on key neurobiological processes, including neuroinflammation, BBB permeability, neurotransmission, and synaptic plasticity, all of which are directly relevant to neurodegeneration and neuroprotection [615, 616]