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For example, when Wendel and coworkers sought to evaluate LPO as a mechanism of APAP-induced cell death, they intended to enhance susceptibility by feeding the animals a vitamin E-deficient diet high in PUFAs

Results Demographics of tissue donors There were no differences in mean age, gender or post-mortem interval between the autism and control groups for either cerebellum or BA22

Cell 154 , 169184 (2013)

Critically, UGT inhibition (not substrate activity) correlates with hepatotoxic potential.A drugs inhibition of UGT enzymes is a direct indicator of increased hepatotoxicity risk