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Thymosin Beta-4 (TB-500)# Thymosin Beta-4 (often studied as its fragment TB-500) is a 43-amino-acid polypeptide involved in actin sequestration, cell migration, and tissue repair

Endogenous prion protein conversion is required for prion-induced neuritic alterations and neuronal death

TB-500 is WADA banned under category S2 (Peptide Hormones, Growth Factors) because its biological activity profile promoting cell migration, tissue repair, and recovery falls under the definition of performance-enhancing substances

The peptide influences vasomotor tone through the Src-caveolin-1-eNOS pathway, affecting both vasoconstriction and vasodilation depending on baseline vascular state