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Physiology 40, e20240028

Bioavailability of NAC significantly increased with increasing dose

In the initial step, chlorine is lost and the -carbon reacts with the nucleophilic nitrogen atom to form the cyclic, positively charged, and very reactive aziridinium moiety

Similarly, reprogramming of glutamine metabolism is also critical for the survival of tumor and immune cells, and competition for glutamine uptake also exists between these cells in the TME