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The American Heart Association provides clear guidelines: General Health: 1g daily of combined EPA and DHA Mild Elevation (150-199 mg/dL): 1-2g daily for 5-10% reduction High Triglycerides (200+ mg/dL): 2-4g daily for 20-30% reduction The FDA recommends limiting omega-3 supplements to 2g daily unless under medical supervision

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Several researchers additionally propose the hypothesis of a feedback loop linking oxidative stress with iron accumulation [66, 67]