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Proc Natl Acad Sci U S A (2012) 109(47):1938691

Still in clinical development, early studies suggest it may deliver even greater weight loss than current drugs, but it is not yet available for general use

Simvastatin hydroxyl acid comes from serial hydrolytic reactions of simvastatin, and it is the active metabolite that inhibits the 3-hydroxy-3-methylglutaryl (HMG)coenzyme A reductase