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The literature concerning hearing ability of animals includes studies of hearing mechanisms and determination of hearing thresholds (audiograms), through primarily behavioral responses to various noise levels in laboratory experiments

Although MacKinnon and colleagues pointed out several reasons for suggesting that there could be distortions in the X-ray structure of KvAP, they concluded that the crystallized full-length channel is not far from a membrane-bound conformation

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It has been reported to have a poor success rate to isolate very specific aptamer (67), leading to the development of in silico SELEX, a computational-based selection that can identify high affinity aptamer, shorten the aptamer selection process within an hour and provide additional information that can be retrieved such aptamer-protein binding site