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Symptoms that are severe, or that last more than a few days and are not improving

Mitochondrial aspects of synaptic dysfunction in Alzheimers disease

doi: 10.1089/ast.2017.1812, 48 KallistovaA.MerkelA.KanapatskiyT.BoltyanskayaY.TarnovetskiiI.PerevalovaA.et al

Proteomic studies further confirmed that ApoE3 improves cerebrovascular function by inducing extracellular matrix-stabilizing proteins such as Timp3, whereas ApoE4 exacerbates pathological progression by suppressing lipoprotein metabolism-related proteins and activating the complement system [88, 91]