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Detoxification problems : Sensitivity to toxins, such as alcohol or pollutants

doi: 10.1016/j.omtm.2021.03.002

Next, we demonstrated in T-cell leukemia and lung cancer cell models that NKX2-1 binds and transcriptionally upregulates serine/glycine synthesis enzyme genes including phosphoserine phosphatase ( PSPH ) and serine hydroxymethyltransferase ( SHMT )