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Today, several clinical trials have shown that an immune response can be elicited by stimulating T lymphocytes, relieving the brake of autoreactivity using immune checkpoint inhibitors (ICI) and/or chimeric antigen receptor (CAR) engineered T or natural killer (NK) cells

the lactate dyscrasia theory) proposes that mitochondrial dysfunction partly contributes to an accumulation of lactate in the junction of motor neurons and muscle cells (the neuromuscular junction (NMJ)) leading to death of both the nerve and muscle cells, thereby requiring the remaining muscle cells to work harder-than-normal to generate the force necessary for motor control