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Secondary endpoints were defined as pharmacodynamics and pharmacokinetic parameters including maximum serum concentration, time to maximum concentration, half-life, plasma clearance, and volume of distribution, as well as exploratory parameters including bodyweight, glycemic control, and overall hormone profile

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Differences in alkaloid profile in kratom plant material is expected to have implications for opioid receptor-mediated activity The alkaloid speciofoline is an oxindole, while the more commonly studied alkaloids mitragynine and 7-hydroxymitragynine are indoles (Scheme 1)