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At the same time, there was no evidence of ERK1/2 phosphorylation in KD cells, which might have contributed to the lingering unimpeded TGF-1 signaling

(C) Acquired resistance mechanisms: Acquired resistance is mediated by secondary mutations in the target protein, activation of alternative pathways through other receptors or downstream proteins, or phenotypic transformation

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doi: 10.1111/bjh.15758 23 GraceR