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However, this adaptation creates a dependency on continuous nutrient and energy supplies, beyond the well-documented glucose metabolism alterations, leading to enhanced production of amino acids and fatty acids to support tumor growth [79, 80]

Prior to phylogenetic tree construction, several sequences were filtered out where isoforms were presented (180), short sequences (19) and alternative splice variants or fragmented sequences (15)

Furthermore, there is concern that chronic supplementation may blunt the free radical-driven adaptive effects of training by interfering with the essential endogenous antioxidant response to ROS [31, 32]