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These results further confirm that oral ATO is well tolerated and has low cardiac toxicity ( Increasing evidence indicates that the liver is not only the primary site for arsenic methylation but also a potential target of arsenic toxicity (Figure 4A)

This can be coupled to research indicating that activities of the main neuroprotectant antioxidant enzymes catalase and glutathione peroxidase have been found to be deficient in patients suffering from depression (Bilici et al., 1996

Protocolized management of infants with congenital diaphragmatic hernia: effect on survival

It is thought that in such mutants both the inactive and the active Meta II photointermediate states have a low interconversion energy barrier, implying that these mutations either destabilize the inactive state or stabilize the active state, or both 11