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The regulation of ferroptosis is multifaceted and involves numerous pathways and biomolecules involved in metabolism, iron regulation, and redox defenses (Figure 1)

EC 2.7.11.25) and protein kinase B (AKT) following cellular production of ROS, suggesting that this chaperone is an important redox-reactive molecule during oxidative stress in PD and other age-related disorders [120]

It is debated whether and to what extent neurons depend on astrocytic lactate, given evidence of their autonomous glycolytic capacity in specific contexts (Tang, 2018