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Contraindications Given the limited safety data, conservative contraindications would include pregnancy or plans to become pregnant, breastfeeding, age under 18, severe liver or kidney disease, and any condition requiring medications with unknown interaction potential

Further, we observed that T cell inhibitory genes ( Ctla4 , Pdcd1 , Lag3 , Havcr2 ) were also elevated in the geriatric T cells

However, if you have normal blood sugar before surgery you are less likely to develop diabetes, and if you recently developed diabetes before surgery you may even see an improvement in your condition

There are no other absolute contraindications reported for hydroxocobalamin use in deficiency states, but caution is advised in individuals with conditions such as early Lebers optic neuropathy (a rare hereditary optic atrophy) due to the theoretical risk of worsening vision