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E has been studied to reduce the overall inflammation in the body thereby reducing the weight which justifies our results thus stating the impact of the dual therapy regime in the management of weight (Reference Saboori, Shab-Bidar and Speakman50Reference Bauer, Heinz and Whybrow52)

Depending on stimuli, microglia can adopt distinct phenotypes: the M1 pro-inflammatory state (induced by lipopolysaccharide and characterized by production of cytokines such as TNF-, IL-1, and IL-6) and the M2 anti-inflammatory state (induced by IL-4 or IL-13, promoting repair) [122, 123]

In a first step, the data was divided into cKOt and control sample subsets and a concatenation strategy was applied to the samples from each genotype separately

p 1 CMRF and no alcohol use [AUDIT-C=0]