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Vitamin B 12 deficiency Reviewed by Howard E

Rather than merely summarizing nutraceutical interventions, the present review reorganizes evidence within defined cytokine-signaling axesincluding NF-B, NLRP3 inflammasome, TGF-/SMAD, JAK/STAT, macrophage polarization, and ferroptosis pathwaysthereby providing a mechanistic roadmap that extends beyond nutrient-class or outcome-based summaries and supports the development of cytokine-guided precision nutrition strategies in NAFLD/MASLD