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(Wu et al., 2019) demonstrated in human umbilical vein ECs and arteries of HHcy mice that Hcy triggers the expression of ER oxidoreductin-1 (Ero1), leading to ER stress and subsequent inflammation

These clinical findings provided important evidence for DSIP's potential therapeutic applications in sleep disorders and stimulated further research into peptide-based approaches to insomnia treatment

"GSH transport in mitochondria: defense against TNF-induced oxidative stress and alcohol-induced defect." Am J Physiol

Interleukin-4 receptor (IL4R), particularly type-II IL4R, is composed of IL4R and IL13R1, and it is upregulated in major tumors such as breast, lung, head and neck tumors and glioblastoma compared to their corresponding control tissues 23,24,25