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These lipid hydroperoxides are unstable and can decompose into secondary oxidative products, such as aldehydes, alkanes, and ketones, with malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE) being notable for their cytotoxic and mutagenic effects [51]

Specifically, analyzed were the affected brain areas (04), cerebral (NTP-7, Level 3), cerebellar cortex (NTP-7, Level 6), and hippocampus, thalamus, and hypothalamus (NTP-7, Level 3) as follows (score 0 indicates no histopathologic change): score 1: small, patchy, complete, or incomplete infarcts (10% of the area affected)

This finding suggests that inhibition of Akt phosphorylation would paradoxically lower fibro-adipogenic depositions but also decrease endogenous compensatory mechanisms and overall muscle function

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