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Studies have reported that disturbances in iron metabolism, encompassing both iron deficiency and iron overload, may result in a dynamic imbalance between bone resorption and formation, contributing to OP [20, 71]

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This can be attributed not only to insufficient knowledge and action in the field of prevention but also to the fact that most kidney diseases are asymptomatic during their initial stages

Eur J Drug Metab Pharmacokinet 47(1):118 Ghavami S, Kerkhoff C, Los M, Hashemi M, Sorg C, Karami-Tehrani F (2004) Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and the effect of metal ions