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reported a 5-year survival rate of 41% after complete resection.[121] In conclusion, metastatic melanoma of the gastrointestinal tract is very rare, but should be suspected in any patient with a history of cutaneous melanoma and new gastrointestinal symptoms

Research in rodent models has characterized MC4R-mediated effects on food intake suppression, energy expenditure, and autonomic outflow, establishing MT-2 as a widely used pharmacological tool for probing central melanocortin circuitry (Huszar et al., Cell, 1997