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For example, bergamottin in grapefruit juice inhibits intestinal CYP3A4, increasing the systemic exposure of drugs such as felodipinean interaction with clear clinical implications ( 3.2.2 Environmental toxicants 3.2.2.1 Airborne pollutants There is a complex association between fine particulate matter (PM2.5) exposure and CYP enzyme expression and function as PM 2.5 contributes to an increased CYP 1A1 expression in multiple tissue types including neutrophils, bronchial epithelial cells, and alveolar macrophage, primarily due to adsorbed aromatic hydrocarbons on their surface