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In the latest international pooled analysis, the adverse associations of TMAO with certain cardiometabolic biomarkers have been elucidated, and the mechanisms of action, independent of renal function, warrant further investigation (96)

Another randomized placebo-controlled trial in 2,330 patients with acute MI, L-carnitine therapy (9 g/day intravenously for five days, then 4 g/day orally for six months) did not affect the risk of heart failure and death six months after MI (50)

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Trimethylamine is a good nucleophile, and this reactivity underpins most of its applications