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Description

The quantity of therapeutic moiety reached at IMM in vivo differs substantially, depending on cell orientation, physicochemical properties of conjugated therapeutic cargo, treatment interval and population of mitochondria

Stamou et al., 2024)

The catalyzed reaction involves the transfer of a sulfuryl group from the 3-phosphoadenosine-5-phosphosulfate (PAPS) to the hydroxyl group of tyrosine residues which are surrounded by clusters of acidic residues, glutamate and aspartate [119,121,123]