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Carotenoid concentrations in your skin plummet, stripping away natural protection against oxidative damage

For immune-focused analysis, we manually selected pathways from Gene Ontology (GO) Biological Processes, KEGG, BioCarta, WikiPathways, Reactome, and Hallmarks MsigDB collections, grouping them into three categories: cytokine, antigen processing/presentation and other immune-related

This increased ROS production is exacerbated by activation of the NADPH oxidase system and increased NADPH levels through the hexose monophosphate shunt, which supports ROS generation [144]