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Description

As a tumor suppressor, YY2 negatively regulates de novo serine synthesis by binding to the PHGDH promoter and repressing its transcriptional activity, thereby inhibiting tumorigenesis (104)

Cell Culture HeLa cells were obtained from the Lerner Research Institute of the Cleveland Clinic Foundation (Cleveland, OH)

Safety, efficacy, and pharmacodynamics of the investigational agent orteronel (TAK-700) in metastatic castration-resistant prostate cancer (mCRPC): updated data from a phase I/II study [abstract 98]