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The siRNA experiments were carried out using HiPerfect Transfection Reagent (QIAGEN, Madrid, Spain) using a control siRNA (SR30005, OriGene, Rockville, USA) or CAR siRNA (SR306706, OriGene)

Transcranial stimulation Among the more innovative treatment strategies, transcranial and non-invasive brain stimulation (NIBS) emerges as an alternative option