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Upon completion, mice were released from the tube, and temperature recording continued for an additional 30 min while they moved freely within the plastic cage (24 17 12 cm)

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To assess whether the senescent phenotype induced by T-DXd was reversible or sustained, we performed washout experiments at different time points: in particular, cells treated with the ADC were allowed to recover in normal growth medium for either 3 or 7 days after the end of treatment