glutathione peroxidase antioxidant.pdf Oxidants and Antioxidants Antioxidant Enzyme Systems

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Another profound nutritional challenge in these conditions is mitochondrial dysfunction

Nonetheless, cancer cells under sustained and increased levels of ROS may overwhelm ROS detoxifying capacity and fail to adapt to further oxidative insults, eventually triggering cell death [5, 7]

p53 inhibits the transcription of SLC7A11 by directly binding to its promoter in fibroblasts and certain cancer cells, which then affects the GPX4-regulated classical pathway and ultimately leads to ferroptosis (Fig