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Nicotinamide Adenine Dinucleotide is a metabolic co-enzyme charged with the vital task of repairing and remodeling DNA

specifically, it inhibits pro-apoptotic mediators such as Bax and cleaved caspase-3 while simultaneously upregulating anti-apoptotic proteins like Bcl-2, thereby stabilizing mitochondrial integrity and obstructing cytochrome-cdependent cascades ( 3.5 Effects on protein aggregation Luteolin exerts its influence on proteostasis through various mechanisms: it has the capacity to diminish the production and aggregation propensity of misfolded proteins indirectly by attenuating oxidative stress and neuroinflammation that promote misfolding, as well as by modulating proteolytic systems (40)