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Retatrutide extends the same class further as a triple receptor agonist, targeting the GLP-1, GIP, and glucagon receptors together, with the added glucagon activity aimed at boosting energy expenditure alongside appetite suppression

However, theres an important caveat: most of the data comes from animal research, not human clinical trials

Although the mean values for each of the alpha diversity measures were often largest for the 5A-1MQ-treated group switched from WD to LD relative to all other groups (Fig