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The most common form of hereditary hemochromatosis (HH) is caused by mutations in the HFE, TFR1, hemojuvelin, hepcidin, or FPN genes

They postulate the pain felt by patients is out of proportion to the damage seen, the pain is not just because cartilage over the bone gets worn down. They state the thin rim of the cartilage becomes inflamed and sends pain signals to the body

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Methods Human pluripotent cell lines The use of the iPSC and ESC lines was reviewed by the Harvard Committee on the Use of Human Subjects (the Harvard IRB) and determined to not constitute human subjects research