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During the polymerase transition from the initiation state to the post-initiation and elongation state, the nascent RNA product gradually grows longer with the addition of the incoming nucleotides, which is accompanied by the conformational changes of the priming and intrusion loops as well as the supporting helix to coordinate the RNA synthesis process (Fig

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Vitamin B12 deficiency typically causes a condition called megaloblastic anaemia making red blood cells too large and reducing their numbers

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