glutathione conjugation of salicylates Phase II Reactions: and Mercapturic Acid Formation in Pharmacokinetics and Pharmacodynamics Frontiers | Glutathione S-Transferase Enzymes

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Excessive peritoneal iron accumulation leads to overproduction of reactive oxygen species (ROS)-a group of highly reactive chemicals formed from oxygen, which at high concentrations can damage DNA, RNA, proteins, and lipids within the cell (20)-and enhanced activation of nuclear factor kappa-B (NF-B), which, by promoting the expression of matrix metalloproteinases (MMPs), exacerbates inflammation, angiogenesis, and cell adhesion

Soucy JR, Todd L, Kriukov E, Phay M, Reh TA, Baranov P