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June 18 Product: AbbVies Skyrizi Indication: Ulcerative colitis AbbVies blockbuster therapy Skyrizi now has further reach after the FDA greenlit the IL-23 antagonist for the treatment of moderately to severely active ulcerative colitis

The purified recombinant MhTyrA p Q227E enzyme (Figure S3) showed decreased PDH activity (Figure 4D) with a substantial gain of ADH activity (Figure 4C, Table 1) without altering cofactor preference (Figure S4)

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