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The mechanism of action of cisplatin (and carboplatin) involves covalent binding to purine DNA bases, which primarily leads to cellular apoptosis

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Thus, the general principle of the selenenylsulfide sensing in the non-reduced TrxR1 is the process of opening selenenylsulfide bond in response to the oxidizing reagents with a highly electrophilic active species

every treated subject may not respond to a particular treatment protocol, regimen, process or remedy, treating does not require that the desired physiologic response or outcome be achieved in each and every subject or subject population, e.g., patient population