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Kennaway DJ

Plant Soil Environ

Reduction of the TXNIP interdomain disulphide bond between Cys63 and Cys190 would make Cys63 available to form an interprotomer disulphide linkage with Cys247 of another TXNIP molecule, as observed in in vivo co-immunoprecipitation and mass spectrometry experiments (Fig

Blocking excessive activation of this factor is a key target for effectively inhibiting the activation of the contact system, and the use of novel inhibitory antibodies to neutralize FXIIa has been shown to reduce the inflammatory response in animal models of ECMO, as well as thrombosis prevention (52, 53)